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The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is a portion of the nephron tubule that connects the loop of Henle to the collecting duct. A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. The process whereby the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell. The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. The process whereby the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DCT cell fate commitment
Acc: GO:0072146
Aspect: Biological Process
Desc: The process whereby the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell.
Synonyms:
  • distal convoluted tubule cell fate commitment
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0072146 - DCT cell fate commitment (interactive image map)
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