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The process by which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA. The process by which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of chromatin silencing by small RNA. The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. The cellular process by which a complex containing RNA and proteins is synthesized, aggregates, and bonds together. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC). Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. Any process by which RNA molecules inactivate expression of target genes. The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference. The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: small RNA loading onto RISC
Acc: GO:0070922
Aspect: Biological Process
Desc: The process by which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA.
Synonyms:
  • gene silencing by RNA, small RNA loading onto RISC
  • RISC assembly
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 26 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070922 - small RNA loading onto RISC (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle