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Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. Catalysis of the hydrolysis of 5'-phosphotyrosyl moieties formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA. Catalysis of the hydrolysis of 3'-phosphotyrosyl moieties formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. Catalysis of the hydrolysis of phosphotyrosyl moieties formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: tyrosyl-DNA phosphodiesterase activity
Acc: GO:0070259
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of phosphotyrosyl moieties formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070259 - tyrosyl-DNA phosphodiesterase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle