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A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals. An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: occluding junction
Acc: GO:0070160
Aspect: Cellular Component
Desc: A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
Synonyms:
  • occluding cell junction
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 215 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070160 - occluding junction (interactive image map)
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Created and Maintained by: Michael Riffle