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Apoptosis that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. Cell death resulting from activation of endogenous cellular processes.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: apoptosis in response to endoplasmic reticulum stress
Acc: GO:0070059
Aspect: Biological Process
Desc: Apoptosis that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Synonyms:
  • endoplasmic reticulum stress-induced apoptosis
  • apoptosis triggered by ER stress
  • ER stress-induced apoptosis
  • apoptosis in response to ER stress
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070059 - apoptosis in response to endoplasmic reticulum stress (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle