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Catalysis of the removal of a methyl group from a substrate. Catalysis of the removal of a methyl group from a histone. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. Catalysis of the reaction: methyl-lysine + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. The methyl-lysine residue is at position 36 of histone 3.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: histone demethylase activity (H3-K36 specific)
Acc: GO:0051864
Aspect: Molecular Function
Desc: Catalysis of the reaction: methyl-lysine + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. The methyl-lysine residue is at position 36 of histone 3.
Synonyms:
  • histone H3-lysine-36 demethylase activity
  • histone-lysine(H3-K36) demethylase activity
  • histone-lysine (H3-K36) demethylase activity
  • [histone-H3]-lysine-36 demethylase activity
  • JHDM1A activity
  • JmjC domain-containing histone demethylase 1A activity
  • protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity
  • H3-K36-specific demethylase activity
  • histone-lysine demethylase activity (H3-K36 specific)
  • protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051864 - histone demethylase activity (H3-K36 specific) (interactive image map)
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