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Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. Any process that stops or reduces the rate of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans. Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. Any process that stops or reduces the rate of ATP hydrolysis by an ATPase. Any process that stops or reduces the activity of a helicase. Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. Any process that stops or reduces the activity of an enzyme. Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. Any process that modulates the activity of an enzyme. Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I. Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of hydrolase activity
Acc: GO:0051346
Aspect: Biological Process
Desc: Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
Synonyms:
  • down-regulation of hydrolase activity
  • inhibition of hydrolase activity
  • hydrolase inhibitor
  • down regulation of hydrolase activity
  • downregulation of hydrolase activity
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 150 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051346 - negative regulation of hydrolase activity (interactive image map)
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