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Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. Any process that mediates the transfer of information from one cell to another. Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation. Any process that stops, prevents or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Any process that stops, prevents or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. Any process that stops, prevents or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. Any process that stops, prevents or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). Any process that stops, prevents or reduces the frequency, rate or extent of a neurophysiological process.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of synaptic transmission
Acc: GO:0050805
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
Synonyms:
  • downregulation of synaptic transmission
  • down-regulation of synaptic transmission
  • inhibition of synaptic transmission
  • down regulation of synaptic transmission
Proteins in PDR annotated with:
   This term: 21 [Search]
   Term or descendants: 56 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0050805 - negative regulation of synaptic transmission (interactive image map)
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