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The regulated release of interleukin-1 from a cell or group of cells. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response. Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells. Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells. Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production. The regulated release of interleukin-1 alpha from a cell or group of cells. The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells. Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of interleukin-1 alpha secretion
Acc: GO:0050712
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells.
Synonyms:
  • down-regulation of interleukin-1 alpha secretion
  • inhibition of interleukin-1 alpha secretion
  • down regulation of interleukin-1 alpha secretion
  • downregulation of interleukin-1 alpha secretion
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0050712 - negative regulation of interleukin-1 alpha secretion (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle