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The regulated release of interleukin-1 from a cell or group of cells. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response. The regulated release of cytokines from a cell or group of cells. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells. Any process that stops, prevents, or reduces the rate of production of a cytokine. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells. Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of a protein from a cell or group of cells. Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells. The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Any process that modulates the frequency, rate, or extent of interleukin-1 production.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of interleukin-1 secretion
Acc: GO:0050711
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells.
Synonyms:
  • down regulation of interleukin-1 secretion
  • downregulation of interleukin-1 secretion
  • down-regulation of interleukin-1 secretion
  • inhibition of interleukin-1 secretion
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0050711 - negative regulation of interleukin-1 secretion (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle