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The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus. Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching. Any process that modulates the frequency, rate or extent of isotype switching. Any process that stops, prevents or reduces the frequency, rate or extent of B cell activation. The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes. Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgE isotypes. Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombination.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of isotype switching to IgE isotypes
Acc: GO:0048294
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgE isotypes.
Synonyms:
  • down regulation of isotype switching to IgE isotypes
  • negative regulation of isotype switch recombination to IgE isotypes
  • downregulation of isotype switching to IgE isotypes
  • inhibition of isotype switching to IgE isotypes
  • negative regulation of class switch recombination to IgE isotypes
  • down-regulation of isotype switching to IgE isotypes
  • negative regulation of class switching to IgE isotypes
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0048294 - negative regulation of isotype switching to IgE isotypes (interactive image map)
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