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Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. Any process that stops, prevents or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. Any process that modulates the frequency, rate or extent of endocytosis. Any process that stops, prevents or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. Any process that stops, prevents or reduces the frequency, rate or extent of endocytosis. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. Any process that stops, prevents or reduces the frequency, rate or extent of receptor internalization. Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of receptor-mediated endocytosis
Acc: GO:0048261
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:
  • inhibition of receptor mediated endocytosis
  • negative regulation of receptor mediated endocytosis
  • down regulation of receptor mediated endocytosis
  • downregulation of receptor mediated endocytosis
  • down-regulation of receptor mediated endocytosis
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0048261 - negative regulation of receptor-mediated endocytosis (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle