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Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cholestanetriol 26-monooxygenase activity
Acc: GO:0047749
Aspect: Molecular Function
Desc: Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O.
Synonyms:
  • CYP27A1
  • cytochrome P450 27A1' activity
  • cholestanetriol 26-hydroxylase activity
  • 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity
  • sterol 27-hydroxylase activity
  • 5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)
  • 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity
  • sterol 26-hydroxylase activity
  • 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity
  • 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity
  • CYP27A
  • cholesterol 27-hydroxylase activity
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0047749 - cholestanetriol 26-monooxygenase activity (interactive image map)
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Created and Maintained by: Michael Riffle