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Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: 2-hydroxyglutarate dehydrogenase activity
Acc: GO:0047545
Aspect: Molecular Function
Desc: Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
Synonyms:
  • alpha-hydroxyglutarate oxidoreductase activity
  • L-alpha-hydroxyglutarate dehydrogenase activity
  • alpha-ketoglutarate reductase activity
  • alpha-hydroxyglutarate dehydrogenase (NAD+ specific)
  • L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase
  • hydroxyglutaric dehydrogenase activity
  • (S)-2-hydroxyglutarate:acceptor 2-oxidoreductase
  • alpha-hydroxyglutarate dehydrogenase activity
  • (S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0047545 - 2-hydroxyglutarate dehydrogenase activity (interactive image map)
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