YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-Oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-Oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate. Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide. Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate. Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. Catalysis of the reaction: ATP + H2O = AMP + diphosphate. Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-Oxo-GTP) = 8-oxo-7,8-dihydroguanosine phosphate (8-Oxo-GMP) + diphosphate. 8-Oxo-GTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nucleoside-triphosphate diphosphatase activity
Acc: GO:0047429
Aspect: Molecular Function
Desc: Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide.
Synonyms:
  • nucleoside-triphosphate diphosphohydrolase activity
  • nucleoside-triphosphate pyrophosphatase activity
Proteins in PDR annotated with:
   This term: 19 [Search]
   Term or descendants: 57 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0047429 - nucleoside-triphosphate diphosphatase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle