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The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen. The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: lysosomal proton-transporting V-type ATPase, V1 domain
Acc: GO:0046612
Aspect: Cellular Component
Desc: The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.
Synonyms:
  • lysosomal hydrogen ion-transporting ATPase V1 domain
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046612 - lysosomal proton-transporting V-type ATPase, V1 domain (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle