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The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen. The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: lysosomal proton-transporting V-type ATPase complex
Acc: GO:0046611
Aspect: Cellular Component
Desc: A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen.
Synonyms:
  • lysosomal membrane hydrogen-transporting ATPase
  • lysosomal hydrogen-translocating V-type ATPase complex
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046611 - lysosomal proton-transporting V-type ATPase complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle