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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling pathway. Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling pathway. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress. Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of JNK cascade
Acc: GO:0046329
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
Synonyms:
  • downregulation of JNK cascade
  • down regulation of JNK cascade
  • inhibition of JNK cascade
  • down-regulation of JNK cascade
Proteins in PDR annotated with:
   This term: 42 [Search]
   Term or descendants: 42 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046329 - negative regulation of JNK cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle