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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. Any process that stops, prevents or reduces the frequency, rate or extent of DNA transposition. Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the telomere. Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. Any cellular process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. Any process that inhibits or decreases the rate of DNA recombination during mitosis. Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombination. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of DNA recombination
Acc: GO:0045910
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombination.
Synonyms:
  • downregulation of DNA recombination
  • down regulation of DNA recombination
  • inhibition of DNA recombination
  • down-regulation of DNA recombination
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 47 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045910 - negative regulation of DNA recombination (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle