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Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any epigenetic process that stops, prevents or reduces the rate of gene expression. Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of gene expression, epigenetic
Acc: GO:0045814
Aspect: Biological Process
Desc: Any epigenetic process that stops, prevents or reduces the rate of gene expression.
Synonyms:
  • down regulation of gene expression, epigenetic
  • down-regulation of gene expression, epigenetic
  • inhibition of gene expression, epigenetic
  • downregulation of gene expression, epigenetic
Proteins in PDR annotated with:
   This term: 9 [Search]
   Term or descendants: 405 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045814 - negative regulation of gene expression, epigenetic (interactive image map)
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