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Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase. Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. Any process that modulates the rate or extent of progression through the cell cycle. The process by which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of cell cycle
Acc: GO:0045786
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
Synonyms:
  • negative regulation of cell cycle progression
  • down-regulation of progression through cell cycle
  • negative regulation of progression through cell cycle
  • down regulation of progression through cell cycle
  • downregulation of progression through cell cycle
  • inhibition of progression through cell cycle
Proteins in PDR annotated with:
   This term: 69 [Search]
   Term or descendants: 263 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045786 - negative regulation of cell cycle (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle