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Any process that modulates the frequency, rate, or extent of a homeostatic process. Any process that stops, prevents or reduces the frequency, rate or extent of bone remodeling. Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. A homeostatic process involved in the maintenance of an internal steady-state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. The process by which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. Any process that stops, prevents or reduces the frequency, rate, or extent of tissue remodeling. Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). Any biological process involved in the maintenance of an internal steady-state. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process. Any process that stops, prevents or reduces the frequency, rate or extent of bone resorption.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of bone resorption
Acc: GO:0045779
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of bone resorption.
Synonyms:
  • downregulation of bone resorption
  • down-regulation of bone resorption
  • inhibition of bone resorption
  • down regulation of bone resorption
Proteins in PDR annotated with:
   This term: 25 [Search]
   Term or descendants: 25 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045779 - negative regulation of bone resorption (interactive image map)
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