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A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle. A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Any process that stops, prevents or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity. A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place. Any process that modulates the rate or extent of progress through the mitotic cell cycle. Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of S phase of mitotic cell cycle
Acc: GO:0045749
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity.
Synonyms:
  • down regulation of S phase of mitotic cell cycle
  • down-regulation of S phase of mitotic cell cycle
  • inhibition of S phase of mitotic cell cycle
  • downregulation of S phase of mitotic cell cycle
Proteins in PDR annotated with:
   This term: 18 [Search]
   Term or descendants: 18 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045749 - negative regulation of S phase of mitotic cell cycle (interactive image map)
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