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The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. The orderly movement of a cell from one site to another, often during the development of a multicellular organism or multicellular structure. The migration of a leukocyte from the blood vessels into the surrounding tissue. Any process that activates or increases the frequency, rate, or extent of cellular extravasation. Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation. The movement of a leukocyte within or between different tissues and organs of the body. Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation. Any process that modulates the frequency, rate, or extent of cellular extravasation. The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation. The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation. Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cellular extravasation
Acc: GO:0045123
Aspect: Biological Process
Desc: The migration of a leukocyte from the blood vessels into the surrounding tissue.
Synonyms:
  • immune cell cellular extravasation
  • transendothelial leukocyte migration
  • leukocyte cellular extravasation
  • leucocyte cellular extravasation
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 18 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045123 - cellular extravasation (interactive image map)
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