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Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. The process of elimination of immature T cells which react strongly with self-antigens. The process by which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. The process of T cell selection that occurs in the thymus. The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus. The process by which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell. The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells. The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. The process by which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: T cell selection
Acc: GO:0045058
Aspect: Biological Process
Desc: The process by which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
Synonyms:
  • T lymphocyte selection
  • T-lymphocyte selection
  • T-cell selection
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 39 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045058 - T cell selection (interactive image map)
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