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A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell. The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. A chromosome found in the nucleus of a eukaryotic cell. The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nuclear replication fork
Acc: GO:0043596
Aspect: Cellular Component
Desc: The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
Proteins in PDR annotated with:
   This term: 54 [Search]
   Term or descendants: 191 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043596 - nuclear replication fork (interactive image map)
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Created and Maintained by: Michael Riffle