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The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell. A process that directly activates any of the steps required for cell death by apoptosis. Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation. The regulated exocytosis of secretory granules by a leukocyte. Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation. Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation. The directed killing of a target cell by a leukocyte. A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. Any process of the immune system that occurs as part of an immune response. The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. Any process involved in the carrying out of an immune response by a T cell. The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cytotoxic T cell degranulation
Acc: GO:0043316
Aspect: Biological Process
Desc: The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.
Synonyms:
  • cytotoxic T cell granule exocytosis
  • cytotoxic T-cell granule exocytosis
  • cytotoxic T-lymphocyte degranulation
  • cytotoxic T-cell degranulation
  • cytotoxic T-lymphocyte granule exocytosis
  • cytotoxic T lymphocyte degranulation
  • cytotoxic T lymphocyte granule exocytosis
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043316 - cytotoxic T cell degranulation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle