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Any process that stops, prevents, or reduces the rate of mast cell degranulation. Any process that modulates the frequency, rate, or extent of mast cell degranulation. The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. Any process involved in the carrying out of an immune response by a mast cell. The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. Any process that stops, prevents, or reduces the rate of leukocyte degranulation. Any process that modulates the frequency, rate, or extent of leukocyte degranulation. Any process that stops, prevents or reduces the frequency, rate, or extent of mast cell activation during an immune response. Any process that modulates the frequency, rate, or extent of mast cell activation during an immune response. Any process that stops, prevents or reduces the frequency, rate, or extent of mast cell activation. The regulated exocytosis of secretory granules by a leukocyte. Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. Any process that stops, prevents or reduces the frequency, rate or extent of exocytosis.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of mast cell degranulation
Acc: GO:0043305
Aspect: Biological Process
Desc: Any process that stops, prevents, or reduces the rate of mast cell degranulation.
Synonyms:
  • down regulation of mast cell degranulation
  • downregulation of mast cell degranulation
  • down-regulation of mast cell degranulation
  • inhibition of mast cell degranulation
  • negative regulation of mast cell granule exocytosis
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043305 - negative regulation of mast cell degranulation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle