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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus. The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer. Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication. A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. Any process that modulates the frequency, rate or extent of DNA replication.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: replication fork arrest
Acc: GO:0043111
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork.
Synonyms:
  • replication fork stalling
  • replication fork blocking
  • negative regulation of DNA replication at replication fork barrier
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043111 - replication fork arrest (interactive image map)
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