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Any process that mediates the adoption of a specific fate by a cell. The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. Any process that restricts, stops or prevents a cell from adopting a specific cell fate. Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. Any process that mediates the specification of a cell into an endoderm cell. Process by which a cell becomes capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. The process by which a cell becomes committed to become part of the endoderm. Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of endodermal cell fate specification
Acc: GO:0042664
Aspect: Biological Process
Desc: Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.
Synonyms:
  • down regulation of endodermal cell fate specification
  • negative regulation of endoderm cell fate specification
  • suppression of endoderm cell fate
  • downregulation of endodermal cell fate specification
  • inhibition of endodermal cell fate specification
  • suppression of endodermal cell fate
  • down-regulation of endodermal cell fate specification
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042664 - negative regulation of endodermal cell fate specification (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle