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Any process that initiates the activity of an inactive protein kinase. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress. The initiation of the activity of the inactive enzyme JUN kinase kinase kinase activity in response to phosphorylation by a member of the MAP kinase kinase kinase kinase (MAPKKKK) family or another upstream kinase. A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: activation of JNKKK activity
Acc: GO:0042655
Aspect: Biological Process
Desc: The initiation of the activity of the inactive enzyme JUN kinase kinase kinase activity in response to phosphorylation by a member of the MAP kinase kinase kinase kinase (MAPKKKK) family or another upstream kinase.
Synonyms:
  • activation of JUN kinase kinase kinase activity
  • positive regulation of JUNKKK activity
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042655 - activation of JNKKK activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle