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The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. The process whereby a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. The process whereby a signal is passed from the insulin receptor to components of the phosphoinositide 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions. The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phosphoinositide 3-kinase cascade involved in insulin receptor signaling
Acc: GO:0035558
Aspect: Biological Process
Desc: The process whereby a signal is passed from the insulin receptor to components of the phosphoinositide 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Synonyms:
  • PI3K cascade involved in signaling from the insulin receptor
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035558 - phosphoinositide 3-kinase cascade involved in insulin receptor signaling (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle