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The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response. Any process that initiates the activity of an inactive protein kinase. A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: activation of MAPKKK activity involved in innate immune response
Acc: GO:0035422
Aspect: Biological Process
Desc: Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035422 - activation of MAPKKK activity involved in innate immune response (interactive image map)
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Created and Maintained by: Michael Riffle