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A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue. A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis. An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: SPOTS complex
Acc: GO:0035339
Aspect: Cellular Component
Desc: A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.
Synonyms:
  • serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035339 - SPOTS complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle