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Catalysis of the temporally-regulated formation of a transmembrane protein hole that allows the passage of ions, causing a lethal, irreversible depolarization of the cell membrane. Catalysis of the temporally-regulated formation of a transmembrane protein hole that directly or indirectly allows murein hydrolyases to access their cell wall substrate. Catalysis of the temporally-regulated formation of a non-specific transmembrane protein hole that allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell. Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient. Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: holin activity
Acc: GO:0034290
Aspect: Molecular Function
Desc: Catalysis of the temporally-regulated formation of a transmembrane protein hole that directly or indirectly allows murein hydrolyases to access their cell wall substrate.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0034290 - holin activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle