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Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: 5-hydroxymethyluracil DNA N-glycosylase activity
Acc: GO:0034043
Aspect: Molecular Function
Desc: Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.
Synonyms:
  • 5-hmU DNA N-glycosylase activity
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0034043 - 5-hydroxymethyluracil DNA N-glycosylase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle