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Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: TSC1-TSC2 complex
Acc: GO:0033596
Aspect: Cellular Component
Desc: A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
Synonyms:
  • tuberous sclerosis complex
  • tuberin-hamartin complex
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 5 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0033596 - TSC1-TSC2 complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle