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Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). The process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features. Any process that modulates the frequency, rate or extent of chondrocyte differentiation. Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation. Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte differentiation. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of chondrocyte differentiation
Acc: GO:0032331
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte differentiation.
Synonyms:
  • down regulation of chondrocyte differentiation
  • down-regulation of chondrocyte differentiation
  • downregulation of chondrocyte differentiation
  • inhibition of chondrocyte differentiation
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 17 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0032331 - negative regulation of chondrocyte differentiation (interactive image map)
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