YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. Any process that modulates the frequency, rate, extent, or location of transcription termination. Transcription termination is the process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. Regulation of transcription through variation in where transcription termination occurs. A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch. Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond a termination site.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: transcriptional attenuation
Acc: GO:0031555
Aspect: Biological Process
Desc: Regulation of transcription through variation in where transcription termination occurs.
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 10 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031555 - transcriptional attenuation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle