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The process by which one or more ubiquitin moieties are added to a protein. Any process that stops, prevents or reduces the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein. Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. A protein modification process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. Any process that modulates the frequency, rate or extent of the addition of ubiquitin moieties to a protein. Any process that stops, prevents or reduces the frequency, rate or extent of the addition of ubiquitin moieties to a protein. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of protein ubiquitination
Acc: GO:0031397
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the addition of ubiquitin moieties to a protein.
Synonyms:
  • downregulation of protein ubiquitination
  • down-regulation of protein ubiquitination
  • down regulation of protein ubiquitination
  • inhibition of protein ubiquitination
Proteins in PDR annotated with:
   This term: 13 [Search]
   Term or descendants: 99 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031397 - negative regulation of protein ubiquitination (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle