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Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein. Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression. Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. The process by which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: primary microRNA processing
Acc: GO:0031053
Aspect: Biological Process
Desc: Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.
Synonyms:
  • primary miRNA processing
  • pri-miRNA processing
Proteins in PDR annotated with:
   This term: 10 [Search]
   Term or descendants: 10 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031053 - primary microRNA processing (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle