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Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: thiamin pyrophosphate binding
Acc: GO:0030976
Aspect: Molecular Function
Desc: Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
Synonyms:
  • diphosphothiamin binding
  • cocarboxylase binding
  • aneurine pyrophosphate binding
  • TPP binding
  • thiamine pyrophosphate binding
Proteins in PDR annotated with:
   This term: 53 [Search]
   Term or descendants: 53 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030976 - thiamin pyrophosphate binding (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle