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The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers. The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. Any process that modulates the frequency, rate or extent of the process of creating protein polymers. Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. Any process that stops, prevents or reduces the frequency, rate or extent of protein complex assembly. Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. Any process that stops, prevents or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. Any process that stops, prevents or reduces the frequency, rate or extent of actin polymerization. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. Any process that stops, prevents or reduces the frequency, rate or extent of the process of creating protein polymers. Assembly of actin filaments by the addition of actin monomers to a filament.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of actin filament polymerization
Acc: GO:0030837
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of actin polymerization.
Synonyms:
  • downregulation of actin filament polymerization
  • down regulation of actin filament polymerization
  • inhibition of actin filament polymerization
  • negative regulation of actin polymerization
  • negative regulation of actin polymerization and/or depolymerization
  • down-regulation of actin filament polymerization
Proteins in PDR annotated with:
   This term: 13 [Search]
   Term or descendants: 58 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030837 - negative regulation of actin filament polymerization (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle