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The process by which small interfering RNAs target cognate mRNA molecules for degradation. The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. The cellular process by which a complex containing RNA and proteins is synthesized, aggregates, and bonds together. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: targeting of mRNA for destruction involved in RNA interference
Acc: GO:0030423
Aspect: Biological Process
Desc: The process by which small interfering RNAs target cognate mRNA molecules for degradation.
Synonyms:
  • RNA interference, targeting of mRNA for destruction
Proteins in PDR annotated with:
   This term: 26 [Search]
   Term or descendants: 26 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030423 - targeting of mRNA for destruction involved in RNA interference (interactive image map)
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