YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. Any process by which RNA molecules inactivate expression of target genes. The process by which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference. The process by which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference. Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: production of siRNA involved in RNA interference
Acc: GO:0030422
Aspect: Biological Process
Desc: Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
Synonyms:
  • production of guide RNAs involved in RNA interference
  • RNA interference, production of guide RNAs
  • RNA interference, production of siRNA
Proteins in PDR annotated with:
   This term: 41 [Search]
   Term or descendants: 53 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030422 - production of siRNA involved in RNA interference (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle