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Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. Any process that stops, prevents or reduces the frequency, rate or extent of megakaryocyte differentiation. Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte. The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: megakaryocyte differentiation
Acc: GO:0030219
Aspect: Biological Process
Desc: The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
Synonyms:
  • megakaryocyte cell differentiation
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030219 - megakaryocyte differentiation (interactive image map)
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