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Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane. The lipid bilayer surrounding the endoplasmic reticulum. Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the lumen. An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor. Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the cytosol. Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: integral to endoplasmic reticulum membrane
Acc: GO:0030176
Aspect: Cellular Component
Desc: Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
Synonyms:
  • ER integral membrane protein
  • integral to ER membrane
Proteins in PDR annotated with:
   This term: 177 [Search]
   Term or descendants: 205 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030176 - integral to endoplasmic reticulum membrane (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle