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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Any process that modulates the frequency, rate or extent of a signaling pathway. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. The process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway. In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses. The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative adaptation of signaling pathway
Acc: GO:0022401
Aspect: Biological Process
Desc: The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:
  • negative adaptation of signal transduction pathway
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 21 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0022401 - negative adaptation of signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle