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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord. Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling. The regionalization process by which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. Any process that modulates the frequency, rate or extent of smoothened signaling. Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
Acc: GO:0021914
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.
Synonyms:
  • negative regulation of smoothened signalling pathway in ventral spinal cord patterning
  • downregulation of smoothened signaling pathway in ventral spinal cord patterning
  • down regulation of smoothened signaling pathway in ventral spinal cord patterning
  • down-regulation of smoothened signaling pathway in ventral spinal cord patterning
  • inhibition of smoothened signaling pathway in ventral spinal cord patterning
  • negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning
  • negative regulation of hh signaling pathway involved in ventral spinal cord patterning
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0021914 - negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning (interactive image map)
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Created and Maintained by: Michael Riffle