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Activation of an amino acid for incorporation into a peptide by a nonribosomal process. The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria. The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. The biosynthetic process whereby peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nonribosomal peptide biosynthetic process
Acc: GO:0019184
Aspect: Biological Process
Desc: The biosynthetic process whereby peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.
Synonyms:
  • non-ribosomal peptide synthesis
  • nonribosomal peptide biosynthesis
  • nonribosomal peptide synthetase
  • non-ribosomal peptide biosynthesis
  • non-ribosomal peptide formation
  • nonribosomal peptide anabolism
  • non-ribosomal peptide biosynthetic process
  • nonribosomal peptide synthesis
  • nonribosomal peptide formation
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 51 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0019184 - nonribosomal peptide biosynthetic process (interactive image map)
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